Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
All Product Categories
-
Calcium Channel Inhibitors
(583)
View all products
-
Calcium Channel Agonists
(35)
View all products
-
Calcium Channel Antagonists
(210)
View all products
-
Calcium Channel Activators
(86)
View all products
-
Calcium Channel Modulators
(46)
View all products
-
Calcium Channel Chemical
(1)
View all products
-
Calcium Channel Inducers
(11)
View all products
-
Calcium Channel Controls
(10)
View all products
-
Calcium Channel Ligands
(7)
View all products
-
Calcium Channel Related Products (1225)
Related Products (1225)
-
Antibodies (29)
-
Related Compound Screening Libraries (1)
-
Calcium Channel Isoform Comparison
-
Bupivacaine hydrochloride monohydrate (Standard)
0 ImagesCat. No.: HY-W415121RCAS No.: 73360-54-0Bupivacaine (hydrochloride monohydrate) (Standard) is the analytical standard of Bupivacaine (hydrochloride monohydrate). This product is intended for research and analytical applications. Bupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain.
-
Pinaverium bromide-d4
0 ImagesCat. No.: HY-111613SPinaverium bromide-d4 is deuterium labeled Pinaverium bromide. Pinaverium bromide is an L-type calcium channel blocker with selectivity for the gastrointestinal tract, effectively relieves pain, diarrhea and intestinal discomfort, provides good therapeutic efficacies without significant adverse effects on Irritable bowel syndrome (IBS) patients.
-
Mioflazine dihydrochloride
0 ImagesCat. No.: HY-U00049BCAS No.: 83898-67-3Mioflazine dihydrochloride is a nucleoside transport inhibitor with sleep-improving activity. Mioflazine dihydrochloride significantly improves cardiac survival after global cardiac ischemia. Mioflazine dihydrochloride reduces the mitochondrial calcium content in guinea-pig. Mioflazine dihydrochloride does not exhibit inotropic effects during induction and nursing.
-
[DArg10, DAla20] TLQP-21
![[DArg10, DAla20] TLQP-21](https://file.medchemexpress.com/product_pic/hy-p1345b.gif "Click to View [DArg10, DAla20] TLQP-21 Product Detail")
0 ImagesCat. No.: HY-P1345B[DArg10, DAla20] TLQP-21, TLQP-21 (HY-P1345) analogue, is a C3aR agonist (EC50: 87 nM for β-arrestin recruitment). [DArg10, DAla20] TLQP-21 elicits calcium influx. [DArg10, DAla20] TLQP-21 slightly but not significantly potentiates adrenergic-induced lipolysis. [DArg10, DAla20] TLQP-21 can be used in the research of inflammatory diseases, metabolic disorders, and neurological conditions.
-
Econazole (Standard)
0 ImagesSynonyms: (±)-Econazol (Standard)Econazole (Standard) ((±)-Econazol (Standard)) is the analytical standard of Econazole (HY-B0885). This product is intended for research and analytical applications. Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage.
-
Levosemotiadil
0 ImagesCat. No.: HY-121535CAS No.: 116476-16-5Levosemotiadil, an S-isomer of semotiadil, exhibits stronger binding affinity to human serum albumin (HSA) compared to its R-isomer counterpart. This study utilized high-performance frontal analysis (HPFA) to demonstrate that levosemotiadil binds approximately three times more strongly to HSA than semotiadil. The binding parameters were evaluated using Scatchard analysis, revealing specific interactions with the diazepam binding site on HSA. The presence of diazepam decreased the binding affinity of both enantiomers, while warfarin did not alter their binding characteristics. These findings highlight levosemotiadil's potential as a Ca- and Na-channel blocker with significant binding preferences for HSA, crucial for understanding its pharmacokinetics and therapeutic effects.
-
L-Ascorbic acid-13C-4
0 ImagesCat. No.: HY-B0166S5CAS No.: 149153-08-2Synonyms: L-Ascorbate-13C-4; Vitamin C-13C-4L-Ascorbic acid-13C-4 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collag
-
D-myo-Inositol-2,4,5-triphosphate sodium salt
0 ImagesCat. No.: HY-175070Synonyms: Ins(2,4,5)P3 sodium salt; 2,4,5-IP3 sodium saltD-myo-Inositol-2,4,5-triphosphate (Ins(2,4,5)P3) (sodium salt) is a second messenger produced in cells by phospholipase C-mediated hydrolysis of phosphatidylinositol-4,5-biphosphate. D-myo-Inositol-2,4,5-triphosphate (sodium salt) can open calcium channels and increase intracellular calcium upon binding to its receptors on the endoplasmic reticulum. D-myo-Inositol-2,4,5-triphosphate (sodium salt) also acts as a partial agonist at rat hepatic IP3 receptors. D-myo-Inositol-2,4,5-triphosphate (sodium salt) can be studied in research on calcium ions signaling pathway.
-
Naltiazem
0 ImagesCat. No.: HY-106810CAS No.: 108383-95-5Synonyms: Ro 23-6152Naltiazem (Ro 23-6152) is a thiazepinone-type calcium antagonist. Naltiazem inhibits platelet aggregation in vitro and in vivo.
-
AZD-1305
0 ImagesCat. No.: HY-111245CAS No.: 872045-91-5AZD-1305 is an antiarrhythmic agent and atrial selective sodium channel/potassium channel blocker, which can significantly prolongs action potential duration and reduces excitability, cause atrial selective ERP prolongation and acute termination of atrial fibrillation. AZD1305 can be used for atrial fibrillation research.
-
Ethacrynic acid-13C2,d5
0 ImagesCat. No.: HY-B1640SCAS No.: 2806111-66-8Synonyms: Etacrynic acid-13C2,d5Ethacrynic acid-13C2,d5 is the deuterium and 13C labeled Ethacrynic acid.
-
Levemopamil
0 ImagesCat. No.: HY-113581CAS No.: 101238-51-1Levemopamil is a calcium channel blocker and 5-HT2 receptor antagonist. Levemopamil exerts renoprotective effects against ischemic acute kidney injury. Levemopamil is applicable to research related to ischemic acute renal failure.
-
MN-05
0 ImagesCat. No.: HY-126939CAS No.: 1835197-63-1MN-05 is a dual neuroprotective and vasodilatory NMDA receptor inhibitor.MN-05 blocks calcium influx, reduces free radical production, and maintains mitochondrial membrane potential in cortical neurons exposed to glutamate.MN-05 dilates aortic rings against phenylephrine-induced contraction.MN-05 protects neurons against glutamate-induced injury in vitro.MN-05 can be used for the research of neurodegenerative diseases.
-
FURNIDIPINE
0 ImagesCat. No.: HY-16213CAS No.: 138661-03-7Synonyms: CRE 319FURNIDIPINE, an orally active cardio-protective agent, possesses anti-arrhythmic and antihypertensive effects.
-
BL-1021
0 ImagesCat. No.: HY-115359CAS No.: 1002331-76-1BL-1021 is an orally active ion channel blocker. BL-1021 significantly reduces symptoms of neuropathic pain without noticeable sedation or cardiac arrhythmias. BL-1021 can be used in the research of acute and chronic pain.
-
ERG-IN-7
0 ImagesCat. No.: HY-184190ERG-IN-7 is a Nav1.5, Cav1.2 and Kv11.1 inhibitor with IC50 values of 10.34 μM, 21.01 μM, and 16.385 μM for human Nav1.5, Cav1.2, and Kv11.1, respectively. ERG-IN-7 prolongs action potentials, reduces conduction velocity, and restores cardiac function. ERG-IN-7 can be used for the research of ventricular arrhythmia.
-
Phenchlobenpyrrone
0 ImagesCat. No.: HY-119492CAS No.: 215036-81-0Phenchlobenpyrrone is a highly selective neuronal calcium antagonist that crosses the blood-brain barrier. Phenchlobenpyrrone mildly inhibits AChE activity. Phenchlobenpyrrone inhibits Aβ aggregation and promotes the clearance of Aβ oligomers. Phenchlobenpyrrone reduces abnormal phosphorylation of Tau protein. Phenchlobenpyrrone may be used in research on Alzheimer's disease.
-
Catharanthine (Standard)
0 ImagesSynonyms: (+)-3,4-Didehydrocoronaridine (Standard)Catharanthine (Standard) is the analytical standard of Catharanthine. This product is intended for research and analytical applications. Catharanthine ((+)-3,4-Didehydrocoronaridine), a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine lowers blood pressure (BP), heart rate (HR). Catharanthine has anti-cancer activity.
-
Atagabalin hydrochloride
0 ImagesCat. No.: HY-14856BCAS No.: 223445-67-8Synonyms: PD 0200390 hydrochlorideAtagabalin hydrochloride (PD 0200390 hydrochloride) is a Voltage-gated Calcium channel α2δ subunit binder with an IC50 of 22 nM. Atagabalin hydrochloride regulates neurotransmitter release by inhibiting calcium influx at high neuronal firing rates. Atagabalin hydrochloride can be used in research related to sleep disorders.
-
Niguldipine
0 ImagesCat. No.: HY-101390BCAS No.: 102993-22-6Niguldipine is a calcium channel blocker with activity in regulating cardiovascular function. Niguldipine can reduce systolic and diastolic blood pressure, thereby increasing heart rate and cardiac output. Niguldipine exhibits dose-dependent and sustained increases in coronary blood flow. Niguldipine also increases perfusion in the kidneys and femoral arteries, but the effect is temporary and to a lesser extent. The effect of Niguldipine on myocardial metabolism is not significant.
